• Since we found miR b p to be differentially

  2021-09-09

  

  Since we found miR-15b-5p to be differentially expressed along the porcine intestine in 31 day old piglets in a former study [10], the entire miRNA family was analyzed in terms of interaction with potential target-genes. In silico analysis predicted miR-15 family members to target the hedgehog sign

• In the pathogenesis of insulin resistance chronic activation

  2021-09-08

  

  In the pathogenesis of insulin resistance, chronic activation of inflammatory pathways plays an important role, and the macrophage/adipocyte inter-communication provides a key mechanism underlying the common disease states of decreased insulin sensitivity [10]. This involves the migration of macroph

• Biochemical assays have provided evidence that prolonged

  2021-09-08

  

  Biochemical assays have provided evidence that prolonged exposure to GPR35 agonists can induce GPR35 internalization [2], [4], [11], [13]. Our finding that neuronal excitability decreased regardless of whether the slices were superfused for a few minutes or incubated for a few hours with GPR35 agoni

• In summary through medicinal chemistry design and

  2021-09-08

  

  In summary, through medicinal chemistry design and computer-assisted conformational modeling, the initial lead was evolved into a series of dihydrobenzofuran derivatives, , as potent GPR119 agonists. Optimization of general structure at various regions of the molecule, including the substituent on d

• GlxI is a member of the superfamily

  2021-09-08

  

  GlxI is a member of the βαβββ superfamily of proteins, consisting of fosfomycin resistance protein (FosA), methylmalonyl-CoA epimerase (MMCE), extradiol dioxygenase (DIOX), mitomycin C resistance protein (MRP) and bleomycin resistance protein (BRP) [29], [30], [31]. These proteins are believed to ha

• bms-690514 br Regulation of Glu transporters The pivotal rol

  2021-09-08

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino bms-690514 calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcrip

• Due to its unusually long pre implantation period the

  2021-09-08

  

  Due to its unusually long pre-implantation period [20,21], the horse conceptus is entirely dependent on histotrophic nutrition for the first 40 days of gestation [22]. During the pre-implantation period, glucose transporters in the endometrium and conceptus membranes must deliver the glucose require

• Recently unimolecular multi functional peptides that combine

  2021-09-08

  

  Recently, unimolecular, multi-functional peptides that combine GLP-1RA activity with L-NMMA citrate and/or GIP activity have been suggested as new therapeutic agents for glycaemic and weight control. In rodents, dual GIP and GLP-1 receptor agonists achieve significantly better glucose control and we

• br Some general considerations on anterior pituitary cell

  2021-09-08

  

  Some general considerations on anterior pituitary cell type, models, sex and drugs Historically, real-time analysis of native endocrine anterior pituitary cell excitability has been somewhat limited and thus much of the pioneering work on anterior pituitary cell excitability and stimulus-secretio

• The role of cell to cell

  2021-09-08

  

  The role of cell-to-cell interactions in coordinating the cells’ behaviour to ensure an appropriate anterior pituitary hormone response is receiving increasing attention. Anterior pituitary Talabostat mesylate interact with neighbouring cells through junctional complexes. As their name implies, the

• The secretase complex comprises four core subunits presenili

  2021-09-08

  

  The γ-secretase complex comprises four core subunits: presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (Aph1), and presenilin enhancer 2 (Pen2) [7], [8]. PS is the catalytic subunit of γ-secretase, and many PS mutations associated with familial AD result in a high Aβ42/Aβ40 ratio [5].

• Neovascularization upon IMQ treatment was observed to differ

  2021-09-08

  

  Neovascularization upon IMQ treatment was observed to different degrees in WT and GAL3-KO mice, whereas the increase in vascular endothelial growth factor mRNA levels was genotype independent. Because we observed lower levels of the cytokines IL-17A, IL-22, IL-23, and TNF-α in IMQ-treated skin of GA

• D appears to be important for receptor

  2021-09-08

  

  D83 appears to be important for receptor function as a mutation to an alanine produced a non-functional channel. Interestingly, maintaining the charge as in D83E produced only a small reduction in GABA sensitivity. Other mutations at this position which included residues capable of hydrogen bonding

• On the contrary the benzhydrol series showed modest activity

  2021-09-08

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the GPCR Compound Library tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to

• In general the FDP gene is involved in isoprenoid

  2021-09-08

  

  In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in

15668 records 562/1045 page Previous Next First page 上5页 561562563564565 下5页 Last page