• GOAT belongs to the super

  2021-12-15

  

  GOAT belongs to the super family of membrane-bound O-acyltransferases (MBOATs). It is encoded by the gene MBOAT4 in human. The protein GOAT is highly conserved from zebrafish to human (Yanagi et al., 2018). GOAT is ubiquitously expressed with abundant expression in the stomach and intestine (Sakata

• Amongst oxidants that we have studied PMS is

  2021-12-15

  

  Amongst oxidants that we have studied, PMS is unique in having a greater effect in deoxygenated cells. The resulting phenotype shows some similarities with the increased cation permeability shown by deoxygenated sickle 84 9 [27]. It is interesting to consider why PMS has this effect. PMS functions a

• br Conclusions Osteoclcastogenesis is regulated by

  2021-12-14

  

  Conclusions Osteoclcastogenesis is regulated by multiple signal transduction pathways. To maintain bone homeostasis, osteoclast cells must achieve a balance regulation of formation, function, and trafficking of its precursors. Here, we proposed a model in which crosstalk between Fas and S1P/S1P1

• DIS used standard methods for locating

  2021-12-14

  

  DIS used standard methods for locating and contacting persons for interview, including the use of phone calls, letters, in person contact, and contact through social media. During this time period, contacts of persons with diagnosed HIV (first-generation contacts) were tested for HIV and, regardless

• br Retrieval requires histamine H receptors in dorsal

  2021-12-14

  

  Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of

• Tylophora atrofolliculata is a centuries used folk

  2021-12-14

  

  Tylophora atrofolliculata is a centuries-used folk medicine for the treatment of rheumatism in China (Jiangsu New Medical College, 1977). One group of its bioactive components is phenanthroindolizidine alkaloids, which have been demonstrated as lead compounds of anti-tumor agents in our previous stu

• Introduction Glycogen synthase kinase GSK

  2021-12-14

  

  Introduction Glycogen synthase kinase-3 (GSK-3) is an enzyme playing multiple roles in animal tissues and organs, and IGF-1, human recombinant receptor is not an exception. Apart from involvement in regulation of apoptosis and survival GSK-3 influences neuronal morphology, synapse formation, memor

• br Materials and methods br Results

  2021-12-14

  

  Materials and methods Results Discussion Chronic neuroinflammation underlies the pathogenesis of HAND (Saylor et al., 2016, Sodhi et al., 2004). Infected immune cells release viral proteins and inflammatory factors which act on microglia, astrocytes, and neurons to produce the synaptodendri

• The life cycle of T

  2021-12-14

  

  The life cycle of T. cruzi requires both vertebrate and invertebrate hosts. In the insect (invertebrate) vector, the protozoan undergoes extracellular replication, whereas in the mammalian (vertebrate) host it replicates by obligate intracellular multiplication (Rodrigues et al., 2014). Hence, the p

• To this end we evaluated novel D analogs for selectivity

  2021-12-14

  

  To this end, we evaluated novel D22 analogs for selectivity to inhibit substrate transport in OCT2, OCT3, and PMAT heterologous cell SCH 527123 systems, and in mouse hippocampal and striatal preparations. Chosen analogs were based upon availability of essential chemical precursors (e.g. 6-substitut

• Underlying this study is the hypothesized importance of insu

  2021-12-14

  

  Underlying this study is the hypothesized importance of insulin and glucose metabolism on bone. In our investigation of GIP and GIPR gene polymorphisms in relation to bone phenotypes in young and old women our findings depict a complex relationship between glucose metabolism genes and bone. In the c

• As many of the above studies highlight several decades of

  2021-12-14

  

  As many of the above studies highlight, several decades of research on Cx43 has revealed that many of these functional roles are attributed to the C-terminal domain (CT) of this protein which cannot be explained by the formation and existence of intercellular channels. Recent findings on the existen

• Gap junction intercellular communication GJIC

  2021-12-14

  

  Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between 84 9 through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1) depends, at least

• The differences in metabolites fermentation characteristics

  2021-12-14

  

  The differences in metabolites, fermentation characteristics in skim milk, and the use of lactose revealed by principal component analysis are shown in Figure 3C. Notably, D-XJ4–12 appeared to be isolated from the rest of the strains mainly due to its lack of ability to use lactose. Lactococcus lac

• Another small compound targeting IBAT has

  2021-12-14

  

  Another small compound targeting IBAT has been evaluated in Phase I clinical trial (EudraCT 2013-001175-21) [86]. The oral administration of A4250 to healthy subjects did not give rise to any serious adverse events, was well tolerated and had a similar safety profile as elobixibat; however, it cause

15668 records 504/1045 page Previous Next First page 上5页 501502503504505 下5页 Last page