• In this work we constructed a versatile platform based on

  2022-01-26

  

  In this work, we constructed a versatile platform based on MoS2-loaded molecular beacon(MB) and HCR for miRNA detection with high sensitivity and low-background. In this method, the G-quadruplex/Thioflavin T (THT) as fluorescent signal output, which possesses a variety of advantages, such as label-f

• br FGF FGFR pathway as predictive factor

  2022-01-26

  

  FGF/FGFR pathway as predictive factor Several studies have identified FGFR1 amplification as the major predictive factor of response to FGFR inhibitors [26], [27]. However, in a recent study on lung cancer cell lines with ponatinib, FGFR1 mRNA and protein expression, together with FGF2 and FGF9 m

• It has been reported that the pathway

  2022-01-26

  

  It has been reported that the pathway upstream of YAP phosphorylation is operative in a tissue or context-specific manner. LPA or S1P bound to their corresponding membrane GPCRs and act through Rho GTPases to activate YAP/TAZ [11]. Consistently, another report showed that activation of PAR1 (a GPCR)

• Previously we have isolated liver FBPase

  2022-01-26

  

  Previously we have isolated liver FBPase from Pelophylax esculentus (former Rana esculenta, Frost et al., 2006) and characterized its kinetic properties (Dziewulska-Szwajkowska and Dzugaj, 1999) on the contrary the muscle FBPase has never been fully characterized. The primary aim of the present pape

• amc 7 australia br Introduction Before planning population b

  2022-01-26

  

  Introduction Before planning population-based genetic analysis or GWAS, it is important to annotate the sequence of the gene because these sequences represent the major sites such as promoter and transcription factor amc 7 australia which may ultimately affect the expression of the gene. Similar

• br Conclusion We have demonstrated that ETB receptors

  2022-01-26

  

  Conclusion We have demonstrated that ETB receptors negatively regulate the expression of AT1 receptors in renal proximal tubule brdu from WKY rats but not in SHRs. Short-term activation of the ETB receptor increases AT1 receptor phosphorylation in WKY cells but decreases it in SHR cells. We conc

• Recently some published studies showed that HBV can induce

  2022-01-26

  

  Recently, some published studies showed that HBV can induce autophagy in vitro and vivo [[19], [20], [21]]. The critical role of autophagy in HBV normal life cycle, such as HBV envelopment, has been gradually accepted by researchers from different laboratories [22,23]. HBV can trigger the autophagic

• Concerning GST we could appreciate that

  2022-01-26

  

  Concerning GST, we could appreciate that when snails were exposed to the chosen concentrations of chlorpyrifos, the activity was not modified. According to this result, Kristoff et al. (2008) and Domingues et al. (2007) showed no effects on GST in B. glabrata and L. variegatus exposed to azinphos-me

• As more genes were identified to

  2022-01-26

  

  As more genes were identified to cause IRDs, a relatively large proportion were found to either cause multiple phenotypes or multiple inheritance patterns. Out of the 112 autosomal genes that are listed in RETNET (as of July 22, 2016) that are known to cause non-syndromic IRDs (RP, LCA, and CRD), 16

• Several studies have sought a cross

  2022-01-26

  

  Several studies have sought a cross-relationship between commensal bacteria-derived metabolites and the Gprs (Blad et al., 2012). Gpr81 is expressed primarily in adipocytes, and hence, lactate-Gpr81 interaction inhibits lipolysis (Cai et al., 2008, Liu et al., 2009). Lactate reduced inflammation by

• Riboflavin br Discussion Agonist and antagonist action at th

  2022-01-25

  

  Discussion Agonist and antagonist action at the GluN1/GluN3 Riboflavin is known to be complex [4], [10]. Recombinant GluN1/GluN3 receptors produce only small excitatory currents in response to glycine, likely because of a combination of activation via GluN3 and desensitization via GluN1 [2], [3]

• Ligand selectivity may directly be

  2022-01-25

  

  Ligand selectivity may directly be related to the conformational landscape explored by GPCRs despite that most GPCRs do not require dimerization for ligand recognition (Mary et al., 2012). Monomer FPRs have traditionally been perceived as receptors that can recognize N-formyl peptides and LXA4. This

• The precise mechanism by which erastin inhibits SLC A

  2022-01-25

  

  The precise mechanism by which erastin inhibits SLC7A11-mediated cystine import it still unknown. The initially proposed mechanism, by which erastin binds a related transport protein, SLC7A5, and inhibits SLC7A11 in trans [25], was revised soon after, and it was suggested that erastin inhibits SLC7A

• Our data show that oxidative stress high levels of

  2022-01-25

  

  Our data show that oxidative stress (high levels of ROS) suppresses the process of lysosomal exocytosis, which would be predicted to impair the expulsion of toxic compounds from cells. Therefore, we propose that ROS have a biphasic effect on the lysosomal clearance: consistent with their role as a s

• br Methods br Results br Discussion

  2022-01-25

  

  Methods Results Discussion In the general population BNP has been established as a marker for CEP-32496 failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above traditional risk factor

15668 records 477/1045 page Previous Next First page 上5页 476477478479480 下5页 Last page