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br Patients and methods br Surgical technique After
2018-10-22
Patients and methods Surgical technique After oral surgeons excised the main tumor, we measured the oral defect and designed the flap myeloperoxidase on the detected perforator by a hand-held Doppler. The central axis of the flap was identified by a line drawn from the anterior superior iliac
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Finally elderly patients are likely to die
2018-10-22
Finally, elderly patients are likely to die from various age-related diseases, such as cardiopulmonary disorders. Additional studies are required to determine whether the superior overall survival outcomes with no statistical significance support the benefit of esophagectomy in elderly patients with
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Ureteral stones are the most common causes of spontaneous ur
2018-10-22
Ureteral stones are the most common causes of spontaneous ureteral rupture. Most patients received ureteroscopy and double-J stenting. Conservative management with guanylyl cyclase can also have a favorable outcome. Most patients experience a sudden onset of abdominal or flank pain. Spontaneous uret
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br Impact on the health
2018-10-22
Impact on the health of humans and other animals — an opportunistic pathogen Cryptosporidium is a significant cause of diarrhoeal disease, principally in humans and livestock throughout the world. The clinical impact of the parasite is greatest in hosts whose Amyloid Beta-peptide (25-35) manufact
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With the future rise in diabetic population worldwide the se
2018-10-22
With the future rise in diabetic population worldwide, the search foractive compounds with α-glucosidase inhibitory activity from medicinal plants has become a very meaningful task. Furthermore, these compounds can be evaluated for potential pharmacological activity against other metabolic diseases.
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br Conflict of interest br Acknowledgement br
2018-10-22
Conflict of interest Acknowledgement Introduction Diabetes mellitus (DM) is a serious global health program which is characterized by high blood glucose levels, which lead to complications such as retinopathy, hypertension, neuropathy and diabetic foot ulcers [1]. Type 2 DM caused by defect
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It is important to note that for the
2018-10-22
It is important to note that for the current signal amplification protocols, there is a trade-off between the sensing range and the detection limit. People have to make wise choices of signal amplification protocols for achievement of satisfied sensing range or detection limit. Briefly, for signal-o
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We have utilized an adenovirus Ad vector
2018-10-22
We have utilized an adenovirus (Ad) vector as a tool for transduction of functional genes into stem cells, because Ad vectors are relatively easy to construct, can be produced at high titers, and mediate efficient and transient gene expression in both dividing and nondividing cells. We have demonstr
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Several studies have investigated the role of mesenchymal st
2018-10-22
Several studies have investigated the role of mesenchymal stem pkd kinase (MSCs) in improving anal sphincter function after direct injection of stem cells to the anal sphincter muscles (Kajbafzadeh et al., 2010; Kang et al., 2008; Lorenzi et al., 2008; Pathi et al., 2012). The results of these stud
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The presence of condensin II
2018-10-22
The presence of condensin II at enhancer/promoter sites occupied by the Mediator coactivator and NIPBL suggests that it is recruited to these sites during transcription activation. To test this model, we used a well-characterized cell system with a stably transfected doxycycline (Dox)-inducible tran
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Identification of miRNA targets is the most important aspect
2018-10-22
Identification of miRNA targets is the most important aspect in understanding the mechanisms by which miRNAs control cell behavior (Huang et al., 2010; Ivan et al., 2008). Several genes have been identified as miR-210 target genes including Casp8ap2, e2f3, ephrin-A3, neuronal pentraxin 1, MNT, RAD52
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gtpase inhibitor br Materials and methods br Results br Disc
2018-10-22
Materials and methods Results Discussion Posttranscriptional regulation mechanisms are now considered to play a key role in the control of gene expression. Regulation occurs mainly through the modulation of mRNA half life or the formation of a translational initiation complex, allowing the
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br Myocardial regeneration after allogeneic stem cell
2018-10-20
Myocardial regeneration after allogeneic stem cell therapy Moreover, as outlined above, a consensus is gaining ground that most of the favourable effects of cell transplantation protocols used until now exert their beneficial effect by a paracrine mechanism of the transplanted SCR7 over the surv
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Recent methods of reprogramming human fibroblasts to iNSCs
2018-10-20
Recent methods of reprogramming human fibroblasts to iNSCs employed genome-integrating lentiviral or retroviral vectors (Kumar et al., 2012; Ring et al., 2012), which may produce insertional mutations and residual or reactivation of transgenes. We used oriP/EBNA-1 episomal vectors to deliver reprogr
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br Funding This work was supported by a
2018-10-20
Funding This work was supported by a grant from the Dutch Technology Foundation STW (project 10507). Disclosures Acknowledgments Introduction Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia in patients with bilateral lung infiltrates. The Berlin defin
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