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Al igual que en cualquier otro
2018-10-25
Al igual que en cualquier otro empleo, oficio o profesión, del trabajo sexual se extrae plusvalía. Solo que la explotación de una actividad de servicios que se encuentra al margen de la regulación laboral se da sin derechos laborales y con formas que generan exclusión y violencia. En el discurso de
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Increase in foreign direct investment FDI may
2018-10-25
Increase in foreign direct investment (FDI) may decrease foreign portfolio investment volatility because it enhances the confidence of foreign investors and brings more investment in the home country (Gozgor & Erzurumlu, 2010). Similarly, Iyer, Rambaldi, and Tang (2003) found that FDI caused FPI whi
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Sirolimus The most common mechanism of colistin
2018-10-25
The most common mechanism of colistin resistance is modification of LPS, a component of cell membrane, which is the first site of action of colistin. To determine whether inner and outer membranes were still present or intact in Col-R and Col-D A. baumannii strains, we visualized the 2 Col-S, 2 Col-
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All these claims led to the
2018-10-24
All these claims led to the paradoxical situation whereby the heart, previously described as a non-renewing organ, has turned into the organ with the highest number of distinct types of resident stem/progenitor cells. However, aside from the Isl-1pos cardiac progenitor cells, which are direct progen
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br Design of donor plasmids If no footprintless
2018-10-24
Design of donor plasmids If no footprintless gene targeting is required or it is intended to introduce larger transgenes, donor plasmids have to be constructed that contain the homology arms flanking the transgenes or selection cassettes coupled to promoters of choice. Similarly, donor plasmids c
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Here we started to address to what extent GFAP ventricular
2018-10-24
Here, we started to address to what extent GFAP+ ventricular cells, denoted as ependymoglia cells (Parish et al., 2007), within and outside of the constitutively active niches are different from each other in the newt telencephalon. We define two different types of ependymoglia cells, which display
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Recently several clinical trials of stem cell based therapy
2018-10-24
Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et
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In the controversial field of
2018-10-24
In the controversial field of pluripotent stem cell research, it is vital to argue on the basis of reliable and solid data that best reflect the actual research situation and are carefully validated. However, available data on recent research activities in this field are often based on abstract sear
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br Results To develop iPSC
2018-10-24
Results To develop iPSC-based model systems of disease, we first prepared a bank of >60 iPSC clones (ten clones per donor; partial set and reprogramming methodology described previously [Mills et al., 2013; Somers et al., 2010]) derived from the dermal fibroblasts of three control individuals wit
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br Funding This work was funded by NIHR GM awarded
2018-10-24
Funding This work was funded by NIHR01GM085456 awarded to Tanja Dominko. Declaration of interest The following are the supplementary data related to this article. Acknowledgements Introduction The identification of culture conditions that promote the expansion of primitive hematopoieti
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The NT formation and NESC to RGPCs transition
2018-10-24
The NT formation and “NESC-to-RGPCs” transition at the onset of neurogenesis are two fundamental events in the early developing AMG 925 (Götz and Huttner, 2005). However, the developmental regulations are unclear due to being hard to definitely control the two stages. In this study, the two stages
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To elucidate whether the expression
2018-10-24
To elucidate whether the expression pattern of Zscan4 has any correlation with ESC proliferation, we monitored Zscan4 activity at single cell level. Also to see whether the rejuvenation factor Zscan4 correlates with the fluctuating wave of ESC pluripotency (Figure S1), we monitored Zscan4 and the pl
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br Experimental Procedures br Author Contributions br
2018-10-24
Experimental Procedures Author Contributions Acknowledgments Our thanks go to Gioia Polidori Francisco for training and discussions, Kate Watt and Yvonne Turnbull for technical and laboratory managerial support, Kadri Oras and Laura Ferguson for experimental support, Po-Lin So and Bruce Con
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Traditionally testing of hPSC lines for gross chromosomal ch
2018-10-24
Traditionally, testing of hPSC lines for gross chromosomal changes employed karyology by chromosome banding of metaphase aldose reductase inhibitors (Amps et al., 2011; Baker et al., 2007). Although karyotyping allows examination of the entire cell genome in a single assay, an often overlooked issu
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FHPI One major drawback of current melanoma therapy is the
2018-10-24
One major drawback of current melanoma therapy is the development of resistance mechanisms against novel therapeutics targeting the MAPK members RAF or MEK. Upon MAPK inhibition, additionally acquired mutations reactivate the MAPK pathway by gain of RAF gene copy numbers (Shi et al., 2012; Villanuev
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