• Several studies have investigated the role of mesenchymal st

  2018-10-22

  

  Several studies have investigated the role of mesenchymal stem pkd kinase (MSCs) in improving anal sphincter function after direct injection of stem cells to the anal sphincter muscles (Kajbafzadeh et al., 2010; Kang et al., 2008; Lorenzi et al., 2008; Pathi et al., 2012). The results of these stud

• The presence of condensin II

  2018-10-22

  

  The presence of condensin II at enhancer/promoter sites occupied by the Mediator coactivator and NIPBL suggests that it is recruited to these sites during transcription activation. To test this model, we used a well-characterized cell system with a stably transfected doxycycline (Dox)-inducible tran

• Identification of miRNA targets is the most important aspect

  2018-10-22

  

  Identification of miRNA targets is the most important aspect in understanding the mechanisms by which miRNAs control cell behavior (Huang et al., 2010; Ivan et al., 2008). Several genes have been identified as miR-210 target genes including Casp8ap2, e2f3, ephrin-A3, neuronal pentraxin 1, MNT, RAD52

• gtpase inhibitor br Materials and methods br Results br Disc

  2018-10-22

  

  Materials and methods Results Discussion Posttranscriptional regulation mechanisms are now considered to play a key role in the control of gene expression. Regulation occurs mainly through the modulation of mRNA half life or the formation of a translational initiation complex, allowing the

• br Myocardial regeneration after allogeneic stem cell

  2018-10-20

  

  Myocardial regeneration after allogeneic stem cell therapy Moreover, as outlined above, a consensus is gaining ground that most of the favourable effects of cell transplantation protocols used until now exert their beneficial effect by a paracrine mechanism of the transplanted SCR7 over the surv

• Recent methods of reprogramming human fibroblasts to iNSCs

  2018-10-20

  

  Recent methods of reprogramming human fibroblasts to iNSCs employed genome-integrating lentiviral or retroviral vectors (Kumar et al., 2012; Ring et al., 2012), which may produce insertional mutations and residual or reactivation of transgenes. We used oriP/EBNA-1 episomal vectors to deliver reprogr

• br Funding This work was supported by a

  2018-10-20

  

  Funding This work was supported by a grant from the Dutch Technology Foundation STW (project 10507). Disclosures Acknowledgments Introduction Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia in patients with bilateral lung infiltrates. The Berlin defin

• Many authors suggest that an increased production

  2018-10-20

  

  Many authors suggest that an increased production of ROS in the beginning of differentiation is an essential factor for adipogenesis (Liu et al., 2012; Zhou et al., 2014; Wang and Hai, 2015). ROS could, in small quantities, act in cell signaling (Mc Bride et al., 2006; Zhang and Gutterman, 2007) and

• Importantly we found that both HIF

  2018-10-20

  

  Importantly, we found that both HIF factors nonredundantly regulate the morphology and behavior of primary mesenchymal progenitors: in the absence of HIFα expression PαS+ mesenchymal progenitors show impaired proliferation, colony forming ability, and differentiation and acquire an elongated and mot

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Intestinal crypts contain stem cells and their transit-amplifying (TA) daughter cells. Cells exiting the proliferative crypts onto the villi terminally differentiate into enterocytes, goblet cells, and enteroendocr

• Following fundamental analysis of pharmacological and

  2018-10-20

  

  Following fundamental analysis of pharmacological and electrophysiological features of suspension-derived CMs, we have demonstrated direct applicability of bioreactor-produced EBs for tissue engineering. While BCT generation from undissociated, contracting spheres was recently shown, this required g

• adenosine receptor In conclusion we have developed

  2018-10-20

  

  In conclusion, we have developed 11 metrics to characterize the structural phenotype of primary and stem cell-derived cardiomyocytes in a way that is biophysically related to their functional proficiency (Feinberg et al., 2012). Moreover, by engineering myocyte shape and tissue architecture, we were

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Adult mesenchymal stromal order Etonogestrel (MSCs), defined in vitro by their potential to contribute to bone-cartilage-fat cell lineages, are currently used for cell-based bone and cartilage therapies because of

• Differentiating PGCLCs in aggregates from i cultured human

  2018-10-20

  

  Differentiating PGCLCs in order BV6 from 4i cultured human pluripotent stem cells initially utilized a 48-h pre-induction step on Vitronectin/Gelatin coated plates in media composed of bFGF and either TGFβ1 or ACTIVIN A. However subsequent experiments showed that the pre-induction step before aggre

• br Heteroplasmy mitochondrial segregation and disease In

  2018-10-20

  

  Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome

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