• Importantly we found that both HIF

  2018-10-20

  

  Importantly, we found that both HIF factors nonredundantly regulate the morphology and behavior of primary mesenchymal progenitors: in the absence of HIFα expression PαS+ mesenchymal progenitors show impaired proliferation, colony forming ability, and differentiation and acquire an elongated and mot

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Intestinal crypts contain stem cells and their transit-amplifying (TA) daughter cells. Cells exiting the proliferative crypts onto the villi terminally differentiate into enterocytes, goblet cells, and enteroendocr

• Following fundamental analysis of pharmacological and

  2018-10-20

  

  Following fundamental analysis of pharmacological and electrophysiological features of suspension-derived CMs, we have demonstrated direct applicability of bioreactor-produced EBs for tissue engineering. While BCT generation from undissociated, contracting spheres was recently shown, this required g

• adenosine receptor In conclusion we have developed

  2018-10-20

  

  In conclusion, we have developed 11 metrics to characterize the structural phenotype of primary and stem cell-derived cardiomyocytes in a way that is biophysically related to their functional proficiency (Feinberg et al., 2012). Moreover, by engineering myocyte shape and tissue architecture, we were

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Adult mesenchymal stromal order Etonogestrel (MSCs), defined in vitro by their potential to contribute to bone-cartilage-fat cell lineages, are currently used for cell-based bone and cartilage therapies because of

• Differentiating PGCLCs in aggregates from i cultured human

  2018-10-20

  

  Differentiating PGCLCs in order BV6 from 4i cultured human pluripotent stem cells initially utilized a 48-h pre-induction step on Vitronectin/Gelatin coated plates in media composed of bFGF and either TGFβ1 or ACTIVIN A. However subsequent experiments showed that the pre-induction step before aggre

• br Heteroplasmy mitochondrial segregation and disease In

  2018-10-20

  

  Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome

• parp apoptosis pathway Human mesenchymal stem cells are adul

  2018-10-20

  

  Human mesenchymal stem parp apoptosis pathway are adult multipotent stromal cells which differentiate into multiple cell types (Bianco et al., 2013; Castro-Manrreza and Montesinos, 2015). While in terms with the expeditious advances in the field of mesenchymal stem cell (MSC) research, the ambiguity

• Mesenchymal cells in the bone marrow

  2018-10-20

  

  Mesenchymal ctap in the bone marrow are multipotent in nature. Since fibrocytes (defined as bone-marrow-derived cells expressing the hematopoietic marker Cd45 and Collagen I) contribute to fibrosis in organs such as kidney, liver, lung, and heart (Duffield et al., 2013; Kisseleva and Brenner, 2012;

• Understanding http www apexbt com media

  2018-10-20

  

  Understanding the regulatory pathways that control the establishment of the different hematopoietic programs and developing methods to identify and isolate progenitors for each are essential to accurately model hematopoiesis in ESC and induced PSC differentiation cultures and ultimately to generate

• In this study we describe an efficient dCas activator

  2018-10-20

  

  In this study, we describe an efficient dCas9 activator with multimeric VP16 activation domain and a simplified method for guide RNA assembly and cloning. We demonstrate that the dCas9 activator can be fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) (Iwamoto et al., 201

• The laminins used in our system were selected because of

  2018-10-20

  

  The laminins used in our system were selected because of their importance in the developing Lenalidomide (Domogatskaya et al., 2012; Miner et al., 2004), the regenerating liver (Martinez-Hernandez and Amenta, 1995; Carlsson et al., 1981), and the liver stem cell niche (Tanimizu et al., 2012; Lorenz

• Introduction The correct functioning of the

  2018-10-20

  

  Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

• FUS binds to DNA as well as to RNA

  2018-10-20

  

  FUS binds to DNA as well as to RNA and regulates the expression of many transcripts in multiple steps of the gene regulation process (Dormann and Haass, 2013). In this study, we used FALS MPCs efficiently oriented into neuronal lineages including HB9-positive motor neurons to observe altered gene re

• We speculate that ROS reduction

  2018-10-20

  

  We speculate that ROS reduction has an important, but not exclusive, regulatory role in the cAMP-mediated maintenance of HSC-like cells. Moreover, cAMP-mediated ROS/p38 reduction and increased CXCR4 receptor expression provide a correlational benefit to HSC-like cells, as low ROS levels specifically

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