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According to Freud a an inner impulse is an
2018-10-23
According to Freud (1915a), an inner impulse is an extremely complex concept that can be understood as a mental stimulus generated inside the organism. An inner impulse is a power of constant impact, which is impossible to escape. The pressure to behave is common in every inner impulse, and these pr
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br miRNAs are small non coding
2018-10-23
miRNAs are small non-coding RNAs affecting the expression of many genes and are regarded as crucial regulators involved in the fine-tuning of all cellular processes. Organ- and disease-specific miRNAs have been described. They are not only found within nfps but also in body fluids, where they are
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In this issue of Kandioler et al analyzed TP mutations
2018-10-23
In this issue of , Kandioler et al. analyzed TP53 mutations which produce a partial functionality of the protein (decreasing its transcriptional activity to less than 75%) in stage III colon cancer patients (). Relevant of this study is that the authors confined their analyses only to stage III pati
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br Role of Sponsors br Author Contributions br Conflicts
2018-10-23
Role of Sponsors Author Contributions Conflicts of Interest Acknowledgments Introduction Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality worldwide. This will be the third cause of deaths worldwide in 2020 according to the WHO. COPD is a lu
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Interestingly these cognitive impairments were not observed
2018-10-23
Interestingly, these cognitive impairments were not observed in a model of T1D, as mice with STZ-induced diabetes performed these tasks at levels similar to age-matched controls. While several studies have demonstrated cognitive dysfunction in rodent models of T1D (Biessels et al., 1996; Ramanathan
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br Introduction Prostate cancer strikes one in
2018-10-23
Introduction Prostate cancer strikes one in six men and is the second leading cause of cancer-related deaths in men after lung cancer in the United States. Prostate cancer arises mainly from prostatic intraepithelial neoplasia (PIN), a precursor lesion that ultimately progresses to adenocarcinoma
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In order to overcome these problems
2018-10-23
In order to overcome these problems, we have developed an Internet-based e-learning system which is in English, and which is available anywhere in the world, and at any time of the day, so that clinicians worldwide can learn how to detect EGC (Yao, 2013). Recently, advanced imaging endoscopy techniq
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br Materials and Methods br Results
2018-10-23
Materials and Methods Results Discussion In the present population-based study, we assessed the relationship between pre-diagnostic Treg to tTL ratios and future cardiovascular events using a highly specific epigenetic assay for the quantification of T cell subsets. After a median follow-up
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In this study we used a
2018-10-23
In this study, we used a murine model of Schistosoma japonicum (S. japonicum) to investigate the roles of miR-146a/b, two upregulated miRNAs identified in our previous study (He et al., 2015), in the progression of hepatic schistosomiasis. We found miR-146 was primarily expressed in hepatic macropha
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Boyle and Beeson argue that a recent report by Sack
2018-10-23
Boyle and Beeson argue that a recent report by Sack et al. () using late arresting genetically attenuated parasites (LAGAP) supports the role of mek162 and complement in controlling parasitemia. In this study, the authors report that immunization with LAGAP induces antibodies against blood stage pa
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The outcome measures of efficacy of antibody replacement the
2018-10-23
The outcome measures of efficacy of antibody replacement therapy are summarized in Table 3 and Fig. 1. Anamnestically patients had a median number of 5.50 infections per year (interquartile range 4.00–8.00; available in 50 patients). In the year prior to ART the median number of antibiotic courses w
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Trained immunity in vertebrates involves epigenetic reprogra
2018-10-23
Trained immunity in vertebrates involves epigenetic reprogramming through histone post-translational modifications, particularly by histone methyltransferases, that enhance the expression of antimicrobial genes during re-infection (Netea et al., 2016; Pereira et al., 2016). Interestingly, most studi
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To summarize our work highlights the facts that
2018-10-23
To summarize, our work highlights the facts that ECs maintain HIV-specific memory B cell responses associated to effective antiviral humoral activities and that Env-specific memory B cell responses are positively associated with the neutralization breadth in HLA-B*57+ ECs. We propose that promoting
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br Conflict of Interest br Author Contributions
2018-10-23
Conflict of Interest Author Contributions Acknowledgements Introduction Previous studies suggest that impaired glucose regulation may be associated with cancer incidence or cancer-related death. This association was found among patients with diabetes mellitus (Hirakawa et al., 2012; Jee
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BMS-650032 manufacturer The Lothian Birth cohorts of
2018-10-23
The Lothian Birth cohorts of 1921 and 1936 are studies that were initiated in 1999 and 2004 respectively, originally aimed at uncovering the genetic determinants of cognitive aging. These are follow up studies to the Scottish mental survey that tested the intelligence of almost all children aged 11
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