• This review focuses on the atomic basis of CRM

  2019-08-24

  

  This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t

• Currently approved anti obesity drugs for

  2019-08-24

  

  Currently approved anti-obesity drugs for long term use such as orlistat, lorcaserin and liraglutide are efficient in reduction of weight gain but are limited in usage due to their adverse effect profile and higher cost (Krentz et al., 2016; Mopuri and Islam, 2017). In Flubendazole to this, plant d

• Allele specific methylation has been

  2019-08-24

  

  Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL Lapatinib manufacturer and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the sam

• It is well known that the tumor suppressor

  2019-08-24

  

  It is well known that the tumor suppressor p53 plays an important role in regulating the sirtuin 1 and cellular senescence [43,46,48]. For example, FOXO4 could interact with P53, which selectively induced apoptosis in senescent cells [48]. In addition, loss of MECP2 was found to lead to the inducti

• A more refined picture of cholinesterase activity

  2019-08-24

  

  A more refined picture of cholinesterase activity patterns may be obtained by measuring ChE activity of the same sample before and after addition of certain cholinesterase inhibitors, with differential specificity for different components of total ChE activity, such as BW284c51 (BW1,5-bis-(4-allyldi

• br Introduction The cys loop ligand

  2019-08-24

  

  Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri

• br Funding This work was supported by intramural funding of

  2019-08-24

  

  Funding This work was supported by intramural funding of the Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen. Acknowledgments Introduction Cyclic adenosine monophosphate (cAMP) is a central second messenger that controls a plethora of vital functions.

• br Acknowledgements We thank Joseph Granger

  2019-08-24

  

  Acknowledgements We thank Joseph Granger and Bryan Neumann for careful reading of this manuscript. This work is supported by NIH grants AG37609 and HL 60306 to TYC and CCYC. Introduction Eleven million tonnes of waste are produced yearly by the European pulp and paper industry (Monte et al.,

• Introduction Taenia solium is the causative agent

  2019-08-24

  

  Introduction Taenia solium is the causative agent of human taeniasis/cysticercosis and porcine cysticercosis, a major health problem and a veterinary economic challenge in developing countries of Latin America, Africa, and Asia. In Mexico, approximately 500 human neurocysticercosis cases were repor

• The Wnt catenin signaling pathway is a downstream target of

  2019-08-24

  

  The Wnt/β-catenin signaling pathway is a downstream target of SOX9 and is involved in a variety of cellular responses, including cell migration, proliferation, and differentiation [14]. Several studies have identified the Wnt/β-catenin signaling pathway as essential for cartilage function, and it is

• Just as Dorin et al and Nguyen

  2019-08-24

  

  Just as Dorin et al. [2] and Nguyen et al. [3] write in regard to their models, our static model can be used to estimate the affinities of dna synthesis inhibitors to albumin and CBG. Dorin et al. [2] estimates the K, but not K, since they find that their model is not particular sensitive towards ch

• To elucidate whether the impact of hypoxia on EGFR

  2019-08-24

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer ibmx driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly different

• br Acknowledgements The study of RING type E s continues

  2019-08-24

  

  Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01

• LJH685 Most enzymes involved in the addition

  2019-08-24

  

  Most LJH685 involved in the addition and removal of ubiquitin bind weakly to an overlapping surface on ubiquitin. Previously, Sidhu and colleagues diversified this surface and then used phage display to screen these libraries of ubiquitin variants (UbVs) for binding to DUBs and E3 ligases (Ernst et

• br Results and Discussion br Conclusions Understanding the c

  2019-08-24

  

  Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes

15767 records 959/1052 page Previous Next First page 上5页 956957958959960 下5页 Last page