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The present study indicates elevated ATX activity
2024-06-27
The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In PR171 receptor to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared a
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In plants altered expression of Aurora kinases
2024-06-27
In plants, altered expression of Aurora kinases results in impaired meiotic divisions followed by the formation of aneuploid or polyploid progenies [21]. This observation is interesting from an evolutionary point of view because it can be assumed that, during evolution, the influence of biotic and a
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The elevated levels of intracellular antioxidant such as red
2024-06-27
The elevated levels of intracellular antioxidant such as reduced glutathione (GSH) are normally oberserved is various tumor Ceftazidime australia which confers the chemoresistant to chemotherapy [59]. Therefore, the induction of oxidative stress via elevation of intracellular ROS and dimunition of
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The results of our in
2024-06-27
The results of our in vivo experiments provide promising evidence that the apelin/APLNR axis is implicated in CCA growth and that targeting this axis with a receptor specific antagonist may help develop effective, tumor directed therapies. Not only do we show decreased proliferation and angiogenesis
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br STAR Methods br Author
2024-06-27
STAR★Methods Author Contributions Acknowledgments We thank Craig D. Wenger and Neva C. Durand for helpful advice, guidance, and discussions. D.H.P. is supported by the NIH National Human Genome Research Institute (NHGRI) (grant R00HG008662) and the Damon Runyon Cancer Research Foundation (D
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br Antioxidant polymers conjugates Natural antioxidants are
2024-06-27
Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic Ketoprofen as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and
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br Angiotensin receptor neprilysin inhibitors Sacubitril val
2024-06-27
Angiotensin receptor-neprilysin inhibitors Sacubitril/valsartan is the first-in-class ARNI, comprising of molecular moieties of valsartan (ARB) and a neprilysin inhibitor prodrug, sacubitril (AHU377) [51]. Upon ingestion, sacubitril is rapidly metabolised into an active neprilysin inhibitor, sacu
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Immunohistochemistry in tissue samples showed the expression
2024-06-27
Immunohistochemistry in tissue samples showed the expression of several nuclear receptor co-activators, including NCOA1, NCOA2, NCOA3, CREBBP, and EP300, in 85–100% of fexofenadine hydrochloride receptor tumors even some of which lacked AR expression (Boorjian et al., 2009). Knockdown of each co-act
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MSG model is well characterized and widely used because it
2024-06-27
MSG model is well characterized and widely used because it is not influenced by dietary components and because it mimics a lesion in the arcuate nucleus and lateral hypothalamus that can occur in chronic obese patients (Moraes et al., 2009, Purkayasta and Cai, 2013). High fat fed diet is amongst the
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Fish aminopeptidases from Alaska Pollack roe
2024-06-27
Fish aminopeptidases from Alaska Pollack roe and tuna pyloric caeca have been reported on [12,13]. More recently, we described the purification of a leucine aminopeptidase from the skeletal muscle of the common carp [14], red sea bream [15] and a lysine aminopeptidases from Japanese flounder [16]. T
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br Conclusion br Introduction Lung cancer is
2024-06-27
Conclusion Introduction Lung cancer is the principal cause of death by cancer and the third most common cancer worldwide (Sorber et al., 2016). Lung cancer has two main types: small cell carcinomas (approximately 20%) and non-small cell lung cancers (NSCLC) (about 80%) (Fan et al., 2016). NSC
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Two cell surface trans membrane receptors
2024-06-27
Two cell-surface trans-membrane receptors have been identified for adiponectin, AdipoR1 and AdipoR2 [21], and adiponectin action is known to signal through these receptors and the docking protein APPL1 [22]. In muscle and liver cells, signal transduction involves the phosphorylation and activation o
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H 89 A decrease in lactate concentration in the
2024-06-26
A decrease in lactate concentration in the incubation medium was observed in samples treated with heparin and 2′,5′-dideoxyadenosine compared with the control (0.05; Fig. 2B). Discussion In the present study we compared the oxidative metabolism and intracellular signals of heparin, the glycosami
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Changes in actin microfilaments are mediated by changes
2024-06-26
Changes in Doxorubicin HCl microfilaments are mediated by changes in extracellular matrix, mechanical stimulation or growth factors intracellular signaling. We observed significant changes in a number of intracellular signaling pathways associated with changes in actin dynamics during hMSCs differe
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Interestingly a homolog of C elegans acr is present
2024-06-26
Interestingly, a homolog of C. elegans acr-23 is present in the A. suum Vanoxerine dihydrochloride (Jex et al., 2011). However, A. suum is not susceptible to monepantel treatment in vivo (Tritten et al., 2011). Our research seeks to advance knowledge on the mode of action of monepantel on nAChRs fr
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