• The study of TcMYH protein is

  2021-11-05

  

  The study of TcMYH protein is a step forward for the characterization of a GO system in T. cruzi. The complete system appears to be present and our findings demonstrate that is important to maintain DNA stability of the nuclear and mitochondrial genomes, particularly in the presence of oxidative str

• The glycine receptor is an

  2021-11-05

  

  The glycine receptor is an ionotropic neurotransmitter receptor coupled to a chloride ion channel. Glycine receptors are typically described as inhibitory and distributed in the spinal cord and brainstem, though mRNA transcription labelling studies in rats show expression in the hippocampus, cingula

• These differences have led to the

  2021-11-05

  

  These differences have led to the recognition that the extent to which transport contributes to shaping postsynaptic signals likely reflects a balance between the density of transporters and the amount of l-glutamate in the synaptic cleft. Consequently, those synapses exhibiting the characteristics

• Transient forebrain ischemia in rodents

  2021-11-05

  

  Transient forebrain ischemia in rodents induces a reduction in expression of mRNA encoding the AMPA receptor subunit GluR265, 66, 67, 68, 69 (Fig. 3). gluR2 mRNA expression is markedly reduced in the CA1 region (the Chlorogenic acid region most vulnerable to ischemia-induced damage), but not in the

• Besides its established insulinotropic actions GIP has been

  2021-11-05

  

  Besides its established insulinotropic actions, GIP has been shown to possess other direct beneficial effects on the beta cell, including stimulation of growth, differentiation, proliferation and survival.21, 22, 23 It has also been shown to stimulate proinsulin gene transcription and translation. M

• br Competing interests br Authors contributions br Transpare

  2021-11-05

  

  Competing interests Authors contributions Transparency document Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may further progress to liver cirrhosis and liver carcinoma

• Pridinol Methanesulfonate Our extensive preliminary data sug

  2021-11-05

  

  Our extensive preliminary data suggest that the loss of p300 (and resulting H3K27ac) is related to inorganic arsenic related diseases. Therefore, it may open a new avenue for alleviating the consequence of H3K27ac, for example, via boosting CBP enzymatic activity for at least partially compensating

• br Retrieval requires histamine H receptors in dorsal hippoc

  2021-11-05

  

  Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of

• Sodium salicylate Main Text There are over small GTPases tha

  2021-11-04

  

  Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, Sodium salicylate dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-

• To determine the functional consequences of

  2021-11-04

  

  To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD

• br Advanced Glycation Endproducts As glucose levels

  2021-11-04

  

  Advanced Glycation Endproducts As glucose levels rise within sensory neurons as a result of hyperglycemia, normal metabolic pathways become overwhelmed and excess glucose is shunted into other ancillary pathways that, under these conditions, become damaging. One consequence of hyperglycemia is th

• To help resolve the question of simple binding versus

  2021-11-04

  

  To help resolve the question of simple binding versus transport, we reasoned that if quercetin is transported by GLUT1, we should be able to block its uptake by other GLUT1 inhibitors. We initially investigated the effects of two newly identified GLUT1 inhibitors, BAY-876 and WZB-117. WZB-117 was fi

• br Discussion The model of a NVU described by

  2021-11-04

  

  Discussion The model of a NVU described by Mathias et al. (2018) has been implemented on the macro scale (see Kenny et al. (2018b)) via a 2D cerebral tissue slice coupled to a vascular tree. In particular, further communication within the tissue slice has been implemented via extracellular ion el

• Nicastrin is heavily glycosylated contributing

  2021-11-04

  

  Nicastrin is heavily glycosylated, contributing 40–70KDa to the molecular weight of human γ-secretase. Among the 16 predicted N-linked glycosylation sites in the ECD, 11 have been unambiguously identified. The glycans appear to mostly stabilize the local structure, thus contributing to the folding a

• The intestinal epithelium is the first line of

  2021-11-04

  

  The intestinal epithelium is the first line of defense against pathogens and noxious agents and exerts a range of physiological activities, including digestion and herpes simplex virus of nutrients. The intestinal wall consists of a series of finger shaped protrusions called villi and invaginations

15720 records 530/1048 page Previous Next First page 上5页 526527528529530 下5页 Last page