• Furthermore new strategies to achieve a total androgen

  2024-10-28

  

  Furthermore, new strategies to achieve a total androgen deprivation namely by blocking either androgen biosynthesis as well as AR are being considered and should be a relevant topic in the near future. A successful example of this approach is galeterone (159), which not only inhibits the CYP17 enzym

• The synthesis of compounds in which the ethyl linker has

  2024-10-28

  

  The synthesis of compounds in which the ethyl linker has been modified to the carbamate and urea derivatives , and is shown in . Thus the diamine was reacted with glycolic Bacitracin to give the alcohol followed by Mitsunobu reaction with phthalimide to give . Deprotection with hydrazine gave t

• Torcetrapib GABAB receptor is associated with brain and beha

  2024-10-28

  

  GABAB receptor is associated with Torcetrapib and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in patien

• br Material and methods br Results br

  2024-10-28

  

  Material and methods Results Discussion This study explores the hypothesis that ASK1, via transcriptional upregulation by E2F1, molecularly defines AT that supports a dys-metabolic obese phenotype in humans. We demonstrate associations between increased visceral-AT ASK1 expression and multi

• br Acknowledgements We thank the National Natural Science Fo

  2024-10-26

  

  Acknowledgements We thank the National Natural Science Foundation of China (41576156), Shandong Province Science and Technology Development Plan (2015GSF121045), Yantai Science and Technology Development Plan (2015ZH078), and the Public Science and Technology Research Funds Projects of Ocean (No.

• The initial demonstration of the potential of MALDI TOF

  2024-10-26

  

  The initial demonstration of the potential of MALDI-TOF MS for testing antifungal susceptibility of pathogenic fungi came from a proof-of-concept study by Marinach et al. [31] who monitored the changes of the proteome of C. albicans SL-327 exposed to different concentrations of fluconazole. Using a

• Introduction Plant pathogenic fungi are major pathogens in

  2024-10-26

  

  Introduction Plant pathogenic fungi are major pathogens in agricultural diseases and the cause of large crop losses worldwide. There are many kinds of plant pathogenic fungi, with various modes of action. For example, Botrytis cinerea (B. cinerea) is the disease pathogen in the economically importa

• A previous review article suggested

  2024-10-26

  

  A previous review article suggested different washout intervals based on specific clinical contexts [4]. While no consensus was reached for the optimal interval between last dose of BV and surgery for CRLM, the authors of the review suggested waiting 6 to 8 weeks after BV before surgery, particularl

• br Eprosartan The AT R antagonist eprosartan is approved

  2024-10-26

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Chlorothiazide and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events,

• The zinc transporter proteins are members of the

  2024-10-26

  

  The zinc transporter proteins are members of the SLC superfamily of metal transporters, and comprise two structurally and functionally different groups, the zinc-importer (ZIP; Zrt-, Irt-like proteins) family (SLC39A), which regulate zinc transport into the cytoplasm from outside the cell and from i

• Recent studies revealed that certain

  2024-10-26

  

  Recent studies revealed that certain plant-derived compounds can also interfere with AR function. One way of such an interference is by modulating its expression levels. This is the case for the two flavonoids quercetin and luteolin that have been reported to repress the function of AR by inhibiting

• br Acknowledgements This work was supported by Programme

  2024-10-26

  

  Acknowledgements This work was supported by Programme Grants from the MRC and the Wellcome Trust (SGC-C and MF). CB was in receipt of a Marie Curie Intra-European Fellowship during part of this work. We thank past and present members of our group for numerous valuable discussions throughout these

• We find that the interaction of NSF

  2024-10-26

  

  We find that the interaction of NSF and SNAP is critically involved in NMDAR-induced PICK1 unclustering. The binding of SNAP to NSF increases the ATPase activity of NSF, which is known to be essential for the unbinding of PICK1 from GluR2 (Hanley et al., 2002). Disruption of the association between

• Nicotinamide The AR signalling pathways play important roles

  2024-10-26

  

  The AR signalling pathways play important roles in several physiopathological processes associated with ischaemia, inflammation, and tumourigenesis [35]. Moreover, A3AR is overexpressed in different tumour Nicotinamide and seems implicated in pro- or anti-apoptotic effects [36]. In particular, activ

• As an alternative to chronic

  2024-10-26

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify Heparin sodium adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilit

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