In this study we describe an efficient dCas activator

2018-10-20

In this study, we describe an efficient dCas9 activator with multimeric VP16 activation domain and a simplified method for guide RNA assembly and cloning. We demonstrate that the dCas9 activator can be fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) (Iwamoto et al., 201

The laminins used in our system were selected because of

2018-10-20

The laminins used in our system were selected because of their importance in the developing Lenalidomide (Domogatskaya et al., 2012; Miner et al., 2004), the regenerating liver (Martinez-Hernandez and Amenta, 1995; Carlsson et al., 1981), and the liver stem cell niche (Tanimizu et al., 2012; Lorenz

Introduction The correct functioning of the

2018-10-20

Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

FUS binds to DNA as well as to RNA

2018-10-20

FUS binds to DNA as well as to RNA and regulates the expression of many transcripts in multiple steps of the gene regulation process (Dormann and Haass, 2013). In this study, we used FALS MPCs efficiently oriented into neuronal lineages including HB9-positive motor neurons to observe altered gene re

We speculate that ROS reduction

2018-10-20

We speculate that ROS reduction has an important, but not exclusive, regulatory role in the cAMP-mediated maintenance of HSC-like cells. Moreover, cAMP-mediated ROS/p38 reduction and increased CXCR4 receptor expression provide a correlational benefit to HSC-like cells, as low ROS levels specifically

br Results br Discussion In the meibomian gland low

2018-10-20

Results Discussion In the meibomian gland, low numbers of LRCs were observed after 28, 42, and 56 days of chase, which fulfill the slow-cycling, undifferentiated, and low population criteria of adult epithelial stem StemRegenin 1 characterized in other tissues (Alonso and Fuchs, 2003; Stepp a

br Results br Discussion Given

2018-10-20

Results Discussion Given the physiological similarities of cardiomyocytes between zebrafish and human (Brette et al., 2008; Nemtsas et al., 2010), the zebrafish has emerged as an outstanding system for studying cardiac development and regeneration, performing cardiac-associated phenotypic scre

Much of our knowledge on DS comes from the documentation

2018-10-20

Much of our knowledge on DS comes from the documentation of symptoms in patients and analysis of mouse models. Although the contribution of both sources has been crucial in gaining a better understanding of the syndrome, the molecular pathways leading to the development of DS are still largely unkno

Hello world!

2018-07-29